Technology
Principles What do we do?
Whole-body Assessment of specific molecular targets
First stage
Patient with e.g. cancer presenting multiple lesions
Biopsy
Precise information but only of one or few lesions
Whole body molecular imaging
Looks at the whole body and shows all the lesions expressing a specific target
Basics Detection of aberrant cells
Targeting moiety Single-domain antibodies
Single-domain antibodies (sdAb)
- Antibody fragment consisting of a single monomeric variable antibody domain
- Also called Nanobody™
Advantages
- High affinity (nM)
- Very specific
- Deep tissue penetration
- Good stability
- Fast clearance
Radiolabeled sdAb
- Easy radiolabeling
- Low radiation burden