Principles What do we do?

Whole-body Assessment of specific molecular targets

Patient

First stage

Patient with e.g. cancer presenting multiple lesions

Biopsy

Biopsy

Precise information but only of one or few lesions

Molecular imaging

Whole body molecular imaging

Looks at the whole body and shows all the lesions expressing a specific target

Basics Detection of aberrant cells

ABSCINT Technology

Targeting moiety Single-domain antibodies

Antibody vs sd Ab

Single-domain antibodies (sdAb)

  • Antibody fragment consisting of a single monomeric variable antibody domain
  • Also called Nanobody™

Advantages

  • High affinity (nM)
  • Very specific
  • Deep tissue penetration
  • Good stability
  • Fast clearance

Radiolabeled sdAb

  • Easy radiolabeling
  • Low radiation burden